Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease
Identifieur interne : 003312 ( Main/Exploration ); précédent : 003311; suivant : 003313Noninvasive cortical stimulation with transcranial direct current stimulation in Parkinson's disease
Auteurs : Felipe Fregni [États-Unis] ; Paulo S. Boggio [Brésil] ; Marcelo C. Santos [Brésil] ; Moises Lima [Brésil] ; Adriana L. Vieira [Brésil] ; Sergio P. Rigonatti [Brésil] ; M. Teresa A. Silva [Brésil] ; Egberto R. Barbosa [Brésil] ; Michael A. Nitsche [Allemagne] ; Alvaro Pascual-Leone [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Brain Mapping, Deep Brain Stimulation (methods), Direct current, Dominance, Cerebral (physiology), Double-Blind Method, Electrodes, Evoked Potentials, Motor (physiology), Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Motor Activity (physiology), Motor Cortex (physiopathology), Motor Skills (physiology), Nervous system diseases, Neurologic Examination, Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Prefrontal Cortex (physiopathology), Statistics as Topic, brain DC polarization, cortical stimulation, motor function, transcranial direct current stimulation.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- methods : Deep Brain Stimulation.
- physiology : Dominance, Cerebral, Evoked Potentials, Motor, Motor Activity, Motor Skills.
- physiopathology : Motor Cortex, Parkinson Disease, Prefrontal Cortex.
- therapy : Parkinson Disease.
- Aged, Brain Mapping, Double-Blind Method, Electrodes, Female, Humans, Male, Middle Aged, Neurologic Examination, Statistics as Topic.
Abstract
Electrical stimulation of deep brain structures, such as globus pallidus and subthalamic nucleus, is widely accepted as a therapeutic tool for patients with Parkinson's disease (PD). Cortical stimulation either with epidural implanted electrodes or repetitive transcranial magnetic stimulation can be associated with motor function enhancement in PD. We aimed to study the effects of another noninvasive technique of cortical brain stimulation, transcranial direct current stimulation (tDCS), on motor function and motor‐evoked potential (MEP) characteristics of PD patients. We tested tDCS using different electrode montages [anodal stimulation of primary motor cortex (M1), cathodal stimulation of M1, anodal stimulation of dorsolateral prefrontal cortex (DLPFC), and sham‐stimulation] and evaluated the effects on motor function—as indexed by Unified Parkinson's Disease Rating Scale (UPDRS), simple reaction time (sRT) and Purdue Pegboard test—and on corticospinal motor excitability (MEP characteristics). All experiments were performed in a double‐blinded manner. Anodal stimulation of M1 was associated with a significant improvement of motor function compared to sham‐stimulation in the UPDRS (P < 0.001) and sRT (P = 0.019). This effect was not observed for cathodal stimulation of M1 or anodal stimulation of DLPFC. Furthermore, whereas anodal stimulation of M1 significantly increased MEP amplitude and area, cathodal stimulation of M1 significantly decreased them. There was a trend toward a significant correlation between motor function improvement after M1 anodal–tDCS and MEP area increase. These results confirm and extend the notion that cortical brain stimulation might improve motor function in patients with PD. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.21012
Affiliations:
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Nitsche</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical Neurophysiology, Georg August University, Goettingen</wicri:regionArea><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Pascual Eone, Alvaro" sort="Pascual Eone, Alvaro" uniqKey="Pascual Eone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Center for Non‐Invasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1693">1693</biblScope><biblScope unit="page" to="1702">1702</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">8E9F0F54FAEB6C66A66CC89C72020DE06A096B6B</idno><idno type="DOI">10.1002/mds.21012</idno><idno type="ArticleID">MDS21012</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Brain Mapping</term><term>Deep Brain Stimulation (methods)</term><term>Direct current</term><term>Dominance, Cerebral (physiology)</term><term>Double-Blind Method</term><term>Electrodes</term><term>Evoked Potentials, Motor (physiology)</term><term>Female</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Motor Activity (physiology)</term><term>Motor Cortex (physiopathology)</term><term>Motor Skills (physiology)</term><term>Nervous system diseases</term><term>Neurologic Examination</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Prefrontal Cortex (physiopathology)</term><term>Statistics as Topic</term><term>brain DC polarization</term><term>cortical stimulation</term><term>motor function</term><term>transcranial direct current stimulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Dominance, Cerebral</term><term>Evoked Potentials, Motor</term><term>Motor Activity</term><term>Motor Skills</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Double-Blind Method</term><term>Electrodes</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Statistics as Topic</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Courant continu</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Electrical stimulation of deep brain structures, such as globus pallidus and subthalamic nucleus, is widely accepted as a therapeutic tool for patients with Parkinson's disease (PD). Cortical stimulation either with epidural implanted electrodes or repetitive transcranial magnetic stimulation can be associated with motor function enhancement in PD. We aimed to study the effects of another noninvasive technique of cortical brain stimulation, transcranial direct current stimulation (tDCS), on motor function and motor‐evoked potential (MEP) characteristics of PD patients. We tested tDCS using different electrode montages [anodal stimulation of primary motor cortex (M1), cathodal stimulation of M1, anodal stimulation of dorsolateral prefrontal cortex (DLPFC), and sham‐stimulation] and evaluated the effects on motor function—as indexed by Unified Parkinson's Disease Rating Scale (UPDRS), simple reaction time (sRT) and Purdue Pegboard test—and on corticospinal motor excitability (MEP characteristics). All experiments were performed in a double‐blinded manner. Anodal stimulation of M1 was associated with a significant improvement of motor function compared to sham‐stimulation in the UPDRS (P < 0.001) and sRT (P = 0.019). This effect was not observed for cathodal stimulation of M1 or anodal stimulation of DLPFC. Furthermore, whereas anodal stimulation of M1 significantly increased MEP amplitude and area, cathodal stimulation of M1 significantly decreased them. There was a trend toward a significant correlation between motor function improvement after M1 anodal–tDCS and MEP area increase. These results confirm and extend the notion that cortical brain stimulation might improve motor function in patients with PD. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Brésil</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>État de São Paulo</li></region><settlement><li>São Paulo</li></settlement><orgName><li>Université de São Paulo</li></orgName></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Fregni, Felipe" sort="Fregni, Felipe" uniqKey="Fregni F" first="Felipe" last="Fregni">Felipe Fregni</name></region><name sortKey="Pascual Eone, Alvaro" sort="Pascual Eone, Alvaro" uniqKey="Pascual Eone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Boggio, Paulo S" sort="Boggio, Paulo S" uniqKey="Boggio P" first="Paulo S." last="Boggio">Paulo S. Boggio</name></region><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name><name sortKey="Boggio, Paulo S" sort="Boggio, Paulo S" uniqKey="Boggio P" first="Paulo S." last="Boggio">Paulo S. Boggio</name><name sortKey="Lima, Moises" sort="Lima, Moises" uniqKey="Lima M" first="Moises" last="Lima">Moises Lima</name><name sortKey="Rigonatti, Sergio P" sort="Rigonatti, Sergio P" uniqKey="Rigonatti S" first="Sergio P." last="Rigonatti">Sergio P. Rigonatti</name><name sortKey="Santos, Marcelo C" sort="Santos, Marcelo C" uniqKey="Santos M" first="Marcelo C." last="Santos">Marcelo C. Santos</name><name sortKey="Silva, M Teresa A" sort="Silva, M Teresa A" uniqKey="Silva M" first="M. Teresa A." last="Silva">M. Teresa A. Silva</name><name sortKey="Vieira, Adriana L" sort="Vieira, Adriana L" uniqKey="Vieira A" first="Adriana L." last="Vieira">Adriana L. Vieira</name></country><country name="Allemagne"><noRegion><name sortKey="Nitsche, Michael A" sort="Nitsche, Michael A" uniqKey="Nitsche M" first="Michael A." last="Nitsche">Michael A. Nitsche</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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